• 60 questions

NCLEX-PN Pharmacology Questions

An unofficial LPN pharmacology practice test on the pharmacological therapies category of the 2026 NCLEX-PN Test Plan.

A multi-dose vial will be used more than once. What does MedlinePlus say to write on the vial?

Pick an answer, then press Check answer. Then you see Correct or Not quite, with the reason. Keys: A to D pick, Enter checks.

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Exam mode: 20 questions, 40 minutes.

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Unofficial practice questions, not affiliated with the National Council of State Boards of Nursing. Bank checked October 8, 2026.

The real exam, as NCSBN describes it

Time limit
300 minutes
Share of the exam
Pharmacological therapies is 13% of items, with a range of 10 to 16%.
Length
At least 85 and at most 150 items, given by computerized adaptive testing. The number depends on your answers.
Breaks
The five hours include all breaks.

Checked October 7, 2026 against 2026 NCLEX-PN Test Plan, NCSBN, effective April 1, 2026 through March 31, 2029. Rules change, so confirm with the agency itself before your test.

NCSBN's own test plans page

All 60 questions

Rights and medication safety 9

  • A client with rheumatoid arthritis has a new prescription for methotrexate tablets. Which schedule error does MedlinePlus warn has caused deaths? MedlinePlus Drug Information (National Library of Medicine), Methotrexate, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • A multi-dose vial will be used more than once. What does MedlinePlus say to write on the vial? MedlinePlus Medical Encyclopedia (National Library of Medicine), Drawing medicine out of a vial, Check Your Medicine. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • A parent plans to measure a child's liquid medicine with a teaspoon from the kitchen drawer. What does MedlinePlus say about flatware spoons? MedlinePlus Medical Encyclopedia (National Library of Medicine), Liquid medication administration. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • A practical nurse scans the client's wristband and the medication package before giving a dose. Which two "rights" does AHRQ's primer say this bar-code check confirms? AHRQ Patient Safety Network, Medication Administration Errors. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • A used fentanyl patch has just been removed. How does MedlinePlus say to dispose of it? MedlinePlus Drug Information (National Library of Medicine), Fentanyl Transdermal Patch, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • Before a heparin injection is given, what does MedlinePlus say to check on the package label, and why? MedlinePlus Drug Information (National Library of Medicine), Heparin Injection, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • During a medication pass a coworker keeps stopping the nurse with questions. What does AHRQ's primer say about interruptions? AHRQ Patient Safety Network, Medication Administration Errors. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • What makes a medication "high-alert", by AHRQ's primer on medication errors? AHRQ Patient Safety Network, Medication Errors and Adverse Drug Events. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).
  • Which rule does the CDC give for safe injections? CDC, Preventing Unsafe Injection Practices. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (rights of medication administration; medication safety practices).

Routes of administration 11

  • A client cannot swallow a morphine extended-release tablet and asks to have it crushed. What does MedlinePlus say? MedlinePlus Drug Information (National Library of Medicine), Morphine, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A client is given tiotropium capsules with an inhaler device. What does MedlinePlus say about the capsules? MedlinePlus Drug Information (National Library of Medicine), Tiotropium Oral Inhalation, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A client is to take 2 puffs from an albuterol inhaler. How long does the client wait between the puffs, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Albuterol Oral Inhalation, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A client who wears contact lenses uses latanoprost eye drops. What does MedlinePlus say about the lenses? MedlinePlus Drug Information (National Library of Medicine), Latanoprost Ophthalmic, What special precautions should I follow?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A client with a fungal infection of the mouth is given nystatin suspension. How is each dose used, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Nystatin, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A practical nurse gives an influenza vaccine into the deltoid muscle. At what angle does the needle enter the skin, by the CDC's vaccine administration chapter? CDC, Pink Book, Chapter 6: Vaccine Administration. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • A vial of NPH insulin looks cloudy. How is it mixed before the dose is drawn up, by MedlinePlus? MedlinePlus Medical Encyclopedia (National Library of Medicine), Giving an insulin injection, Filling the Syringe - one Type of Insulin. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • How is a nitroglycerin sublingual tablet taken, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Nitroglycerin Sublingual, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • How is nitroglycerin ointment put on the skin, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Nitroglycerin Topical, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • Where is an epinephrine auto-injector given in an emergency, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Epinephrine Injection, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).
  • Where on the abdomen may a subcutaneous injection be given, by MedlinePlus? MedlinePlus Medical Encyclopedia (National Library of Medicine), Subcutaneous (SQ) injections, Choose Your Injection Site. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (administer medication by each route).

Adverse effects to report 20

  • A client says, "The diarrhea would not stop, so I took many more loperamide capsules than the label says." Which serious problem does the important warning for loperamide name? MedlinePlus Drug Information (National Library of Medicine), Loperamide, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client starting isoniazid for tuberculosis is asked about alcohol use. Which organ does the important warning for isoniazid name? MedlinePlus Drug Information (National Library of Medicine), Isoniazid, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client takes phenelzine. Which foods does MedlinePlus say can cause a serious reaction? MedlinePlus Drug Information (National Library of Medicine), Phenelzine, What special dietary instructions should I follow?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client takes spironolactone and lisinopril. Which electrolyte level can these medicines raise, by MedlinePlus's potassium test page? MedlinePlus Medical Encyclopedia (National Library of Medicine), Potassium test, What Abnormal Results Mean. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking atorvastatin reports new muscle pain and weakness with a fever. What does MedlinePlus say to do? MedlinePlus Drug Information (National Library of Medicine), Atorvastatin, What side effects can this medication cause?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking ciprofloxacin reports pain and swelling at the back of the ankle. Which warned problem does this suggest? MedlinePlus Drug Information (National Library of Medicine), Ciprofloxacin, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking clonidine tablets runs out and misses several days. What can stopping clonidine suddenly cause, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Clonidine, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking furosemide reports ringing in the ears. What does MedlinePlus say about this symptom? MedlinePlus Drug Information (National Library of Medicine), Furosemide, What side effects can this medication cause?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking lithium has had severe diarrhea and heavy sweating for two days. Why is this reported? MedlinePlus (National Library of Medicine): Lithium, What special precautions should I follow?, and Lithium toxicity (medlineplus.gov/ency/article/002667.htm). Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking metoprolol feels well and wants to stop the tablets today. What can stopping suddenly cause, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Metoprolol, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking risperidone has a fever, stiff muscles, sweating and confusion. What does MedlinePlus say about these symptoms? MedlinePlus Drug Information (National Library of Medicine), Risperidone, What side effects can this medication cause?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client taking valproic acid has ongoing pain that starts in the stomach area and spreads to the back, with nausea and vomiting. Which warned problem do these symptoms suggest? MedlinePlus Drug Information (National Library of Medicine), Valproic Acid, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A client who began allopurinol last week has a new itchy rash. What does MedlinePlus say to do? MedlinePlus Drug Information (National Library of Medicine), Allopurinol, What side effects can this medication cause?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • A phenytoin level comes back at 26 mcg/mL. How does this compare with the usual target on MedlinePlus? MedlinePlus Medical Encyclopedia (National Library of Medicine), Therapeutic drug levels, Normal Results. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • An hour after a first dose of morphine a client is breathing slowly, with long pauses between breaths. What does MedlinePlus say this calls for? MedlinePlus Drug Information (National Library of Medicine), Morphine, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • The spouse of a client taking zolpidem says the client got up in the night, cooked a meal and remembers none of it. How does MedlinePlus treat this? MedlinePlus Drug Information (National Library of Medicine), Zolpidem, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • Which blood test is ordered during treatment with clozapine, by its important warning? MedlinePlus Drug Information (National Library of Medicine), Clozapine, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • Which rare, life-threatening condition does the important warning for metformin name? MedlinePlus Drug Information (National Library of Medicine), Metformin, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • Which side effect does MedlinePlus list for amlodipine? MedlinePlus Drug Information (National Library of Medicine), Amlodipine, What side effects can this medication cause?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).
  • Which two problems does MedlinePlus's important warning for gentamicin injection name? MedlinePlus Drug Information (National Library of Medicine), Gentamicin Injection, IMPORTANT WARNING. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (evaluate client response to medication).

Reinforcing client teaching 10

  • A client feels better after three days of cephalexin and wants to save the rest of the capsules. What does MedlinePlus say? MedlinePlus Drug Information (National Library of Medicine), Cephalexin, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client is to inject insulin lispro solution at mealtimes. When is it usually injected, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Insulin Lispro Injection, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client starting metronidazole asks about drinking wine. What does MedlinePlus say? MedlinePlus Drug Information (National Library of Medicine), Metronidazole, What special precautions should I follow?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client takes a cold remedy, a sleep aid and a pain tablet that all contain acetaminophen. What daily total does MedlinePlus say not to exceed from all sources? MedlinePlus Drug Information (National Library of Medicine), Acetaminophen, What special precautions should I follow?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client takes bisacodyl tablets at night with a glass of milk. Which point does MedlinePlus make about dairy products? MedlinePlus Drug Information (National Library of Medicine), Bisacodyl, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client taking rifampin wears soft contact lenses and uses birth control pills. Which two points does MedlinePlus make? MedlinePlus Drug Information (National Library of Medicine), Rifampin, What special precautions should I follow?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A client with asthma has both fluticasone and albuterol inhalers. During a sudden attack, what does MedlinePlus say about fluticasone? MedlinePlus Drug Information (National Library of Medicine), Fluticasone Oral Inhalation, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • A parent gives a child liquid iron (elixir). How does MedlinePlus say to avoid staining the teeth? MedlinePlus Drug Information (National Library of Medicine), Iron Supplements, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • How is an alendronate tablet taken, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Alendronate, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).
  • When are sucralfate tablets taken in relation to meals, by MedlinePlus? MedlinePlus Drug Information (National Library of Medicine), Sucralfate, How should this medicine be used?. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (reinforce education to client regarding medications).

Dose and flow rate calculations 10

  • A 500 mL bag of IV fluid runs at 75 mL per hour. How long will the bag last? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A child weighs 22 kg. The prescription is 10 mg per kg, and the suspension is labelled 100 mg in 5 mL. How many mL make the dose? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A prescription reads 24 units of U-100 insulin. How many units does 1 mL of U-100 insulin hold, and what volume is 24 units? MedlinePlus Medical Encyclopedia (National Library of Medicine), Giving an insulin injection, Getting Ready. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A prescription reads amoxicillin 375 mg by mouth. The bottle is labelled 250 mg in 5 mL. How many mL make the dose? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A prescription reads digoxin 0.25 mg by mouth. The tablets on hand are 0.125 mg each. How many tablets make the dose? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A prescription reads heparin 5,000 units subcutaneously. The vial is labelled 10,000 units per mL. How many mL make the dose? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • A prescription reads levothyroxine 0.075 mg. The tablets are labelled 25 mcg. How many tablets make the dose? NIST, Metric (SI) Prefixes. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • An IV piggyback of 50 mL is to run over 20 minutes on a pump. What rate in mL per hour is set? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • An IV piggyback of 100 mL is to run over 30 minutes by gravity, through tubing that gives 20 drops per mL. What is the drip rate, to the nearest drop? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).
  • An order reads 1,000 mL of IV fluid over 12 hours by gravity, through tubing that gives 15 drops per mL. What is the drip rate, to the nearest drop? Own question; the answer is arithmetic on the numbers in the question. Outline: 2026 NCLEX-PN Test Plan, Pharmacological Therapies (perform calculations; calculate intravenous flow rate).

How it works

These 60 NCLEX-PN pharmacology practice questions are our own, written to the pharmacological therapies category of the 2026 test plan. They are unofficial, not affiliated with, endorsed by or sponsored by the National Council of State Boards of Nursing (NCSBN).

Read the full guide

What this category covers

The activity statements for pharmacological therapies in the 2026 NCLEX-PN Test Plan, read October 7, 2026, name the rights of medication administration, each route, counting controlled substances, evaluating the client's response, reinforcing teaching and calculations with IV flow rates.

Timing

Exam mode asks 20 of the 60 in 40 minutes: two minutes each, the pace of 150 items in five hours.

Where the drug facts come from

Each drug fact names the MedlinePlus drug page or other public page it was read in, and a calculation answer is arithmetic on the question's own numbers. No drug handbook or review book was used.

  • Drugs appear under their generic names, as the MedlinePlus pages list them.

Questions and answers

Is this an LPN pharmacology practice test?

Yes. LPN and LVN candidates sit the NCLEX-PN, and this LPN pharmacology test follows its pharmacological therapies category at the practical nurse's scope: giving medication, monitoring the response and reinforcing teaching.

How much of the NCLEX-PN is pharmacology?

The 2026 test plan weights pharmacological therapies at 13% of items, with a stated range of 10 to 16%. On a minimum-length exam of 52 content-area items that is about seven.

Are these real NCLEX-PN pharmacology questions?

No. The test plan says disclosing exam items is a violation of law. All 60 are our own, written from public drug pages, and none repeats or rewords an item of the exam, of NCSBN's samples or of a review book.

Is there dosage calculation practice?

Ten questions: tablets, liquids, a weight-based dose, a unit conversion, insulin and heparin units, two drip rates, a pump rate and an infusion time.