• 70 questions

CPHON Practice Questions

Unofficial CPHON exam practice on childhood cancers, blood disorders, treatment, symptom care and emergencies, weighted like the outline.

A child has anaphylaxis during a drug infusion. Which medicine should be used immediately if it is available?

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Unofficial practice questions, not affiliated with the Oncology Nursing Certification Corporation (ONCC). Bank checked October 14, 2026.

The real CPHON exam, as its certifying body describes it

Questions
165
Time limit
180 minutes
Fee
$300 for ONS or APHON members, $420 for nonmembers
Retakes
After the current Authorization to Test expires, and not more than once in a 90-day eligibility period; a one-year wait after three fails within three years
Format
Multiple choice: a question or incomplete statement followed by four answers, one of them correct
Scored questions
125 of the 165 count toward the score; 40 are pretest questions, and candidates are not told which
Scoring
A scaled score from 25 to 75; 55 passes. Pass or fail shows on screen at the test center
Session
The three hours include 15 minutes for a tutorial and a survey, with no scheduled breaks
Testing window
90 days from the Authorization to Test

Checked October 14, 2026 against 2026 Certification Test Registration Manual, oncc.org. Rules change, so confirm with the agency itself before your test.

ONCC's own CPHON page

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All 70 questions

Care continuum 4

  • A family chooses hospice care for their child. What have they decided? MedlinePlus Medical Encyclopedia, "Hospice care", Making the Decision to Start Hospice. Outline: ONCC CPHON Test Content Outline, I. Care Continuum.
  • A woman had a higher dose of chest radiation for childhood Hodgkin lymphoma and does not have dense breasts. When is a yearly mammogram suggested to start? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Second Cancers. Outline: ONCC CPHON Test Content Outline, I. Care Continuum.
  • Over time the spleen stops working in sickle cell disease. Which health maintenance step lowers the risk for infection? MedlinePlus Medical Encyclopedia, "Sickle cell disease", Symptoms and Treatment. Outline: ONCC CPHON Test Content Outline, I. Care Continuum.
  • Three years after the end of leukemia treatment, a child has a health problem caused by that treatment. What is a problem like this called? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", General Information About Late Effects. Outline: ONCC CPHON Test Content Outline, I. Care Continuum.
Show all 70 questions (66 more)

Nursing practice: cancers and blood disorders 13

  • A 6-year-old has loss of balance and a morning headache that goes away after vomiting. Medulloblastoma forms in which part of the brain? National Cancer Institute, "Childhood Medulloblastoma and Other Central Nervous System Embryonal Tumors Treatment (PDQ), Patient Version", General Information, symptoms. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • A 10-year-old is offered a place in a clinical trial. What is assent? National Cancer Institute, "Are Clinical Trials Safe?", Children's assent. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • A child inherits the sickle cell gene from only one parent. What does the child have? MedlinePlus Medical Encyclopedia, "Sickle cell disease", Causes. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • A parent sees a white pupil in photographs of a 1-year-old. Which tumor has "white pupil" as a sign and occurs most often before age 2? National Cancer Institute, "Retinoblastoma Treatment (PDQ), Patient Version", General Information About Retinoblastoma. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • An infant is born with aniridia. As part of WAGR syndrome, this raises the risk of which tumor? National Cancer Institute, "Wilms Tumor (PDQ), Patient Version", Causes and risk factors for Wilms tumor; Monitoring children at risk of Wilms tumor. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • By age and white blood cell count at diagnosis, which child is in the standard-risk group for acute lymphoblastic leukemia? National Cancer Institute, "Childhood Acute Lymphoblastic Leukemia (PDQ), Patient Version", Risk groups for childhood acute lymphoblastic leukemia. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • In neuroblastoma biomarker testing, what is MYCN amplification? National Cancer Institute, "Neuroblastoma Treatment (PDQ), Patient Version", General Information About Neuroblastoma, MYCN amplification study. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • Lymph node tissue from a teenager shows large, abnormal lymphocytes that may contain more than one nucleus. What are these cancer cells of Hodgkin lymphoma called? National Cancer Institute, "Childhood Hodgkin Lymphoma Treatment (PDQ), Patient Version", General Information About Childhood Hodgkin Lymphoma. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • Most Ewing sarcomas result from a reciprocal translocation between which chromosomes? Wikipedia, "Ewing sarcoma", Genetics. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • What do researchers work out in a phase 1 clinical trial? National Cancer Institute, "How Do Clinical Trials Work?", Phases of clinical trials. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • Which three findings are called B symptoms in the staging of Hodgkin lymphoma? National Cancer Institute, "Childhood Hodgkin Lymphoma Treatment (PDQ), Patient Version", General Information About Childhood Hodgkin Lymphoma, signs. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • Which urine finding can be a sign of neuroblastoma? National Cancer Institute, "Neuroblastoma Treatment (PDQ), Patient Version", General Information About Neuroblastoma, urine catecholamine studies. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.
  • Why are most people with hemophilia A male? MedlinePlus Medical Encyclopedia, "Hemophilia A", Causes. Outline: ONCC CPHON Test Content Outline, II. Pediatric Hematology and Oncology Nursing Practice.

Treatment modalities and side effects 15

  • A 5-year-old has newly diagnosed immune thrombocytopenic purpura after a viral infection. What is the usual course in children? MedlinePlus Medical Encyclopedia, "Immune thrombocytopenic purpura (ITP)", Causes and Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • A bone marrow or stem cell transplant can cure sickle cell disease. Why is it not an option for most people? MedlinePlus Medical Encyclopedia, "Sickle cell disease", Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • A child with thalassemia major has regular blood transfusions. Which treatment removes the excess iron that builds up? MedlinePlus Medical Encyclopedia, "Thalassemia", Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • A teenager with severe aplastic anemia is to have a bone marrow transplant. With which donor does the treatment work best? MedlinePlus Medical Encyclopedia, "Aplastic anemia", Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • After an allogeneic stem cell transplant, what happens in graft-versus-host disease? National Cancer Institute, "Stem Cell Transplants in Cancer Treatment", Graft-versus-host disease (GVHD). Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • How does desmopressin work in mild hemophilia A? MedlinePlus Medical Encyclopedia, "Hemophilia A", Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • How does hydroxyurea help a child with sickle cell disease? Wikipedia, "Hydroxycarbamide", lead section; MedlinePlus Medical Encyclopedia, "Sickle cell disease", Treatment. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • Radioactive MIBG is used to find neuroblastoma and, in high doses, to treat it. Why may an iodine solution be given with it? National Cancer Institute, "Neuroblastoma Treatment (PDQ), Patient Version", General Information About Neuroblastoma, MIBG scan. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • Vincristine and intrathecal methotrexate are due for the same child on the same day. Which fact about vincristine matters most? Wikipedia, "Vincristine", lead section and Medical uses. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • What is done to a patient's own T cells in CAR T-cell therapy? National Cancer Institute, "CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers", A "Living Drug". Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • What is the most common treatment for Wilms tumor? National Cancer Institute, "Wilms Tumor (PDQ), Patient Version", Types of treatment for Wilms tumor, Surgery. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • What is the third phase of treatment for childhood acute lymphoblastic leukemia, often given in lower doses than the first two? National Cancer Institute, "Childhood Acute Lymphoblastic Leukemia (PDQ), Patient Version", Treatment phases of childhood acute lymphoblastic leukemia. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • Which drug is given with ifosfamide or cyclophosphamide to reduce hemorrhagic cystitis? Wikipedia, "Mesna", Medical uses, Chemotherapy adjuvant. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • Why do all children with acute lymphoblastic leukemia receive CNS-directed therapy such as intrathecal chemotherapy? National Cancer Institute, "Childhood Acute Lymphoblastic Leukemia (PDQ), Patient Version", CNS-directed therapy. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.
  • Why is folinic acid (leucovorin) given after methotrexate? Wikipedia, "Folinic acid", Medical uses, To reduce the effects of methotrexate. Outline: ONCC CPHON Test Content Outline, III. Treatment Modalities and Side Effects.

Symptom management and supportive care 18

  • A 15-year-old is about to start treatment that may affect fertility. Which option is open before treatment to patients who have reached puberty? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Reproductive System. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • A child vomits on reaching the clinic, before chemotherapy starts, when she smells the treatment room. Which type of nausea and vomiting is this? National Cancer Institute, "Nausea and Vomiting and Cancer Treatment", What are nausea and vomiting?. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • A child's platelet count is low after chemotherapy. Which over-the-counter medicines can increase the risk of bleeding? National Cancer Institute, "Bleeding and Bruising (Thrombocytopenia) and Cancer Treatment", Ways to manage bleeding and bruising. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • A survivor who took dexamethasone has part of a hip bone die from a lack of blood flow. What is this late effect called? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Musculoskeletal System, Chemotherapy and other drug therapy. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • After chemotherapy that included an alkylating agent such as cyclophosphamide, or etoposide, which second cancer may appear less than 10 years after the first diagnosis? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Second Cancers. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Blood components for some children are irradiated before transfusion. Which donor cells cause transfusion-associated graft-versus-host disease? Wikipedia, "Transfusion-associated graft-versus-host disease", lead section and Prevention. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • During chemotherapy, which temperature is listed as a sign of infection to report to the health care team? National Cancer Institute, "Infection and Neutropenia during Cancer Treatment", the list of signs of infection. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • What is the main dose-limiting side effect of vincristine? Wikipedia, "Vincristine", Side effects. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • What is the most commonly observed adverse effect of filgrastim, a medicine used to treat a low neutrophil count? Wikipedia, "Filgrastim", Adverse effects. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • When do the symptoms of a hemolytic transfusion reaction most often appear? MedlinePlus Medical Encyclopedia, "Hemolytic transfusion reaction", Symptoms and Treatment. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • When may palliative care be provided during a child's cancer care? National Cancer Institute, "Palliative Care in Cancer", When is palliative care used in cancer care?. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Where does a central venous catheter that is attached to an implanted port end? MedlinePlus Medical Encyclopedia, "Central venous catheters - ports", introduction and What is the Purpose of a Central Venous Catheter and Port?. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Which chemotherapy is named as raising the risk of hearing loss in childhood cancer survivors? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Senses, Hearing. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Which drug, given during anthracycline treatment, may lessen later damage to the heart and blood vessels? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Cardiovascular System. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Which hormone problem is a common late effect of radiation to the brain in childhood cancer survivors? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Endocrine System, Hypothalamus and pituitary gland. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Which mouth care is part of everyday oral care for a child during chemotherapy? National Cancer Institute, "Oral Complications of Cancer Therapies (PDQ), Patient Version", Managing Oral Complications During and After Chemotherapy or Radiation Therapy, Regular Oral Care. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Which tool assesses pain in a child between 2 months and 7 years old, or in anyone unable to communicate pain? Wikipedia, "FLACC scale", lead section. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.
  • Why is the risk of late effects in the teeth and jaws higher in survivors who were younger than 5 years at the time of treatment? National Cancer Institute, "Late Effects of Treatment for Childhood Cancer (PDQ), Patient Version", Digestive System, Teeth and jaws. Outline: ONCC CPHON Test Content Outline, IV. Symptom Management and Supportive Care.

Hematologic and oncologic emergencies 15

  • A 2-year-old with sickle cell disease has left-sided pain, a swollen spleen, pale skin and a sudden drop in hemoglobin. Which emergency is this? Wikipedia, "Sickle cell disease", Signs and symptoms, Splenic sequestration crisis. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • A child has anaphylaxis during a drug infusion. Which medicine should be used immediately if it is available? MedlinePlus Medical Encyclopedia, "Anaphylaxis", Treatment. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • A child with a tumor beside the spine has back pain, loss of feeling in the legs and urinary retention. Which drug may reduce edema around the lesion and protect the cord? Wikipedia, "Spinal cord compression", Signs and symptoms and Treatment. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • A vesicant chemotherapy drug leaks into the tissue around a peripheral IV. What is the first step? Wikipedia, "Extravasation (intravenous)", Treatment. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Above which leukemia blood cell count do symptoms of leukostasis start? Wikipedia, "Leukostasis", lead section and Signs and symptoms. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • After a brain tumor a child is very thirsty and loses water rapidly as dilute urine. Which hormone is low in central diabetes insipidus? MedlinePlus Medical Encyclopedia, "Central diabetes insipidus", Causes and Treatment. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • After a CAR T-cell infusion a child develops cytokine release syndrome. Which drug, which blocks the activity of IL-6, can manage it? National Cancer Institute, "CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers", Managing the side effects of CAR T-cell therapies. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • After high-dose chemotherapy before a bone marrow transplant, a child gains weight from fluid retention, the liver enlarges and bilirubin rises. Which complication is this? Wikipedia, "Hepatic veno-occlusive disease", lead section. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • In a child with sickle cell disease and fever, cough and chest pain, which chest x-ray finding commonly shows acute chest syndrome? Wikipedia, "Acute chest syndrome", lead section and Signs and symptoms. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • In SIADH the body retains too much water and blood sodium falls. What is the first step of treatment in all cases? MedlinePlus Medical Encyclopedia, "Syndrome of inappropriate antidiuretic hormone secretion", Treatment. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Rasburicase, a uric acid lowering drug used in tumor lysis syndrome, is contraindicated in which condition because it may cause sudden, severe hemolysis? Wikipedia, "Rasburicase", Contraindication. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Typhlitis, a neutropenic enterocolitis, is an inflammation of which part of the bowel? Wikipedia, "Neutropenic enterocolitis", lead section and Signs and symptoms. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Which of these is among the common side effects of asparaginase given by injection? Wikipedia, "Asparaginase", lead section. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Which set of blood results characterizes tumor lysis syndrome? Wikipedia, "Tumor lysis syndrome", lead section and Prevention. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.
  • Which three findings make up Cushing's triad, a response to increased intracranial pressure? Wikipedia, "Cushing reflex", lead section. Outline: ONCC CPHON Test Content Outline, V. Pediatric Hematologic and Oncologic Emergencies.

Psychosocial dimensions of care 5

  • A 2-year-old in the hospital can no longer dress himself or use the toilet he had just mastered. Which of Erikson's crises is at stake in toddlerhood? Wikipedia, "Erikson's stages of psychosocial development", Stages. Outline: ONCC CPHON Test Content Outline, VI. Psychosocial Dimensions of Care.
  • A child goes back to school after brain tumor treatment and has trouble learning. Which US law ensures students with a disability a free appropriate public education? Wikipedia, "Individuals with Disabilities Education Act", lead section. Outline: ONCC CPHON Test Content Outline, VI. Psychosocial Dimensions of Care.
  • How do children aged 3 to 6 years tend to understand death? National Cancer Institute, "Grief, Bereavement, and Loss (PDQ), Patient Version", Children and Grief, a child's understanding of death. Outline: ONCC CPHON Test Content Outline, VI. Psychosocial Dimensions of Care.
  • Parents begin to grieve while their child is still alive and receiving end-of-life care. Which type of grief is this? National Cancer Institute, "Grief, Bereavement, and Loss (PDQ), Patient Version", Types of Grief. Outline: ONCC CPHON Test Content Outline, VI. Psychosocial Dimensions of Care.
  • Which of Piaget's stages, lasting until about age seven, includes magical thinking and egocentric thinking? Wikipedia, "Piaget's theory of cognitive development", Preoperational stage. Outline: ONCC CPHON Test Content Outline, VI. Psychosocial Dimensions of Care.

How this list was compiled: Our own questions, written to the CPHON Test Content Outline of the Oncology Nursing Certification Corporation (https://www.oncc.org/sites/default/files/2024-11/2025_CPHON_Test_Content_Outline.pdf, linked from https://www.oncc.org/certified-pediatric-hematology-oncology-nurse-cphon, read 2026-10-14), in its weights: care continuum 6%, pediatric hematology and oncology nursing practice 18%, treatment modalities and side effects 21%, symptom management and supportive care 26%, pediatric hematologic and oncologic emergencies 21%, psychosocial dimensions of care 8%. The bank holds 4, 13, 15, 18, 15 and 5 questions in that order. Every fact was read on 2026-10-14 in the public page the question names: the National Cancer Institute's PDQ summaries and treatment pages, the MedlinePlus Medical Encyclopedia of the National Library of Medicine, and the Wikipedia articles named on the questions. Licence: Questions, choices and explanations are original work of this site.

How it works

These free CPHON practice questions are our own, written to the test content outline of the Certified Pediatric Hematology Oncology Nurse exam. They are unofficial: this site is not affiliated with or endorsed by the Oncology Nursing Certification Corporation (ONCC).

Read the full guide

What the CPHON exam covers

ONCC's test content outline, read October 14, 2026, weights the care continuum 6%, pediatric hematology and oncology nursing practice 18%, treatment modalities and side effects 21%, symptom management and supportive care 26%, emergencies 21% and psychosocial dimensions of care 8%. The 70 questions are split 4, 13, 15, 18, 15 and 5.

Pace of the timed test

The timed test here asks 33 questions in 33 minutes: a fifth of the real exam's 165 questions, at about a minute each.

Where the answers come from

Each clinical fact names the public page it was read in: the National Cancer Institute's PDQ summaries for childhood cancers and late effects, the MedlinePlus Medical Encyclopedia for blood disorders, and named Wikipedia articles for drug effects and emergencies.

  • ONCC tests use only generic drug names, and so do these questions.
  • By ONCC's manual every major area of the outline is on every form of the test, but not every sub-area.

Questions and answers

How many questions are on the CPHON exam?

165 multiple-choice questions in a three-hour session, by ONCC's 2026 test registration manual. 125 count toward the score and 40 are pretest questions. Candidates are not told which are which.

What is the passing score for the CPHON exam?

A scaled score of 55, on a scale that runs from 25 to 75, by ONCC's manual. The pass or fail result shows on the screen before the candidate leaves the test center.

Is this the ONCC CPHON practice test?

No. ONCC has its own free 50-question CPHON practice test at oncc.org/practice-tests and sells one more. The questions here are ours, written from the public outline and the public page each one names.

Who can take the CPHON exam?

By ONCC's manual: a registered nurse with a current, active, unencumbered license, two years of RN experience and 2,000 hours of pediatric oncology or hematology nursing practice within four years, and 10 contact hours of oncology continuing education within three.

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